NEW PRESENTATION: PREDICTING PHARMACOKINETICS FOLLOWING TOPICAL APPLICATION USING NON-ANIMAL METHODS

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Physiologically Based Pharmacokinetic (PBPK) models are routinely used to predict human kinetic profiles of compounds. The ADME information required to build these models can be generated using differing approaches from purely in silico, through in vitro models, to extrapolation from animal models. We present an evaluation of how well current non-animal methods can accurately predict human pharmacokinetics of topically applied compounds. Hepatic metabolism data was generated in four different in vitro model systems using primary human hepatocytes with the aim of investigating the most appropriate system to study low clearance compounds. Dermal absorption rate information was generated by both in silico and in vitro approaches.

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