NEW POSTER: EVALUATION OF A NEXT GENERATION RISK ASSESSMENT (NGRA) APPROACH FOR SKIN ALLERGY USING SIX INGREDIENTS AND TWO PRODUCT TYPES

Share

Our aim is to apply mechanistic and clinical understanding to develop a Next Generation Risk Assessment (NGRA) approach for skin allergy that doesn’t require new animal test data, addresses novel exposure scenarios and better characterises our uncertainty. Our NGRA approach for skin allergy is a tiered approach that integrates predictive chemistry expertise, historical in vivo data and existing or new in vitro data using two model-based approaches to predict the probability of human skin sensitisation occurring following a given product exposure, with explicit uncertainty. Our NGRA approach has been evaluated using six case study ingredients and two product types, conclusions and next steps are shared as part of this poster presentation.

 

View the poster.

Comments are closed.