Potential Roles of Omics Data in the use of Adverse Outcome Pathways for Environmental Risk Assessment, Liverpool, September 2014

Currently there are substantial international efforts to develop and catalogue Adverse Outcome Pathways (AOPs) and develop implementation guidance for risk assessment. ‘Omics approaches offer potential for use in environmental risk assessment when applied as part of a systems toxicology or integrative approach, and considered in the context of the AOP framework. For example, omics can provide mechanistic information about the effects of chemicals and have the potential to increase confidence in species extrapolation.

In September 2014, Unilever in collaboration with the University of Liverpool and the International Environmental Omics Synthesis Centre co-hosted a one day workshop addressing the ‘Potential Roles of Omics Data in the use of Adverse Outcome Pathways for Environmental Risk Assessment’. The workshop brought together key experts in the field from academia, Industry and regulatory organisations to discuss and define the role of ‘omics’ techniques as part of the AOP framework to support environmental risk assessment of chemicals. Specific areas discussed (and key challenges identified) included how we can use ‘omics to help define AOPs and understand species sensitivity differences and the role of data-driven computational learning and its integration with mechanistic approaches in extrapolating from molecular events to population relevant endpoints.

Environmental Risk Assessment Workshop, Liverpool Sept 2014

 

 

 

 

 

 

Click on the links below for the workshop agenda and to download the Introductory presentation.

Workshop Agenda: Potential Roles of Omics Data in the use of Adverse Outcome Pathways for Environmental Risk Assessmentges in the environmental risk assessment of chemicals

A view on current challenges in the environmental risk assessment of chemicals