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New Publication: The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment

New Publication: The Role of Omics in the Application of Adverse Outcome Pathways for Chemical Risk Assessment
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In conjunction with the second International Environmental Omics Symposium (iEOS) held at the University of Liverpool in September 2014, a workshop was held to bring experts from academia, government and industry. The purpose of this workshop was to review the specific roles that high-content molecular-level datasets (e.g. […]

New Publication: Development of a two – dimensional model for predicting transdermal permeation with the follicular pathway: Demonstration with a caffeine study

New Publication: Development of a two – dimensional model for predicting transdermal permeation with the follicular pathway: Demonstration with a caffeine study
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Development of a new two-dimensional (2D) model to predict follicular permeation and integrate with recently developed general purpose model of transdermal permeation. Then validate the integrated model with published clinical data of transdermal permeation of caffeine and analyse the relative importance of the follicular pathway. To view […]

New Poster: Next-generation approaches to assess the safety of oral and skin human microbiome reprofiling

New Poster: Next-generation approaches to assess the safety of oral and skin human microbiome reprofiling
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Bacterial DNA sequencing data generated in recent years have shown that the microbiome profile associated with health differs from that observed during disease states. Although what constitutes a healthy oral and skin microbiota is still not well defined, there is ever-increasing understanding of the organisms naturally present […]

New Presentation: Dosing for Controlled Exposure (DoCE)

New Presentation: Dosing for Controlled Exposure (DoCE)
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Andrew Scott & Chris Sparham introduced the DoCE challenge at the NC3Rs CRACK-IT Challenge launch event in London on the 7th September 2017. The challenge is co-Sponsored by Unilever & Shell and aims to accelerate the application of improved dosing systems to control exposure in vitro. This […]

New Presentation: The Role of glutathione in allergic contact dermatitis

New Presentation: The Role of glutathione in allergic contact dermatitis
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PhD viva presentation at the University of Liverpool. Allergic Contact Dermatitis is a skin condition that affects up to twenty percent of the North American and Western European population. The molecular initiating event (MIE) of this type IV delayed hypersensitivity is the formation of antigenic species by […]

New Poster: Metabolic network analysis of Pseudomonas aeruginosa persister cells

New Poster: Metabolic network analysis of Pseudomonas aeruginosa persister cells
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Persister cells are transient phenotypic variants in a bacterial population that are able to tolerate antimicrobial treatment. These cells have been implicated in the recalcitrant nature of chronic infections and in the resistance to disinfection and preservation systems that can lead to contamination of industrial products. While […]

New Presentation: Next Generation Risk Assessment: Applying 21st Century Safety Science to ensure cosmetics safety for consumers

New Presentation: Next Generation Risk Assessment: Applying 21st Century Safety Science to ensure cosmetics safety for consumers
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Product safety assessment is undergoing a paradigm shift from the traditional animal-based toxicity testing methods to novel, human cells-relevant, toxicity pathway-based in vitro approaches, coupled with in silico models. This change has been driven by new cosmetics regulations on animal testing ban across multiple authorities (e.g., European […]

New Poster: Mapping the resistance and metabolic pathways associated with preservative exposure in an industrial Pseudomonas aeruginosa strain

New Poster: Mapping the resistance and metabolic pathways associated with preservative exposure in an industrial Pseudomonas aeruginosa strain
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Pseudomonas aeruginosa is a common contaminant relating to product-recall in the home and personal care (HPC) industry. Preservation systems prevent spoilage and protect consumers; however, there is limited knowledge of resistance mechanisms utilised in response to preservatives. The aim of this research was to predict key functional […]

New Publication: Application of a spatially resolved model to contextualise monitoring data for risk assessment of down-the-drain chemicals over large scales.

New Publication: Application of a spatially resolved model to contextualise monitoring data for risk assessment of down-the-drain chemicals over large scales.
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Evaluation of ScenAT using TCS and LAS. To view the publication, please follow the link.

New Publication: The T cell response to the contact sensitizer Paraphenylenediamine is characterized by a Polyclonal Diverse repertoire of antigen-specific receptors

New Publication: The T cell response to the contact sensitizer Paraphenylenediamine is characterized by a Polyclonal Diverse repertoire of antigen-specific receptors
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T cell antigen specificity is determined by the T cell receptor, a heterodimeric protein coded for by an extremely diverse set of genes produced by imprecise somatic gene recombination. High throughput sequencing allows millions of different T cell receptor genes to be characterised from a single sample […]