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New Presentation: Redox and Cellular Stress in Relation to Consumer Risk Assessments

New Presentation: Redox and Cellular Stress in Relation to Consumer Risk Assessments
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Many compounds for which consumer safety risk assessments need to be conducted are not associated with specific toxicity modes of action, but rather exhibit non-specific toxicity leading to cell stress (e.g. oxidative stress, mitochondrial toxicity, ER stress). These can lead to the activation of stress-response pathways which, […]

New Publication: A Study of Inter-Individual Variability in the Phase II Metabolism Xenobiotics in Human Skin

New Publication: A Study of Inter-Individual Variability in the Phase II Metabolism Xenobiotics in Human Skin
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Understanding skin metabolism is key to improve in vitro to in vivo extrapolations used to inform risk assessments of topically applied products. However, published literature is scarce and usually covers a limited and non-representative number of donors. We developed a protocol to handle and store ex vivo […]

New Poster: Evaluating HPC ingredients in WWTPs & surface water of the Songhua Catchment using monitoring & high tier modelling tools

New Poster: Evaluating HPC ingredients in WWTPs & surface water of the Songhua Catchment using monitoring & high tier modelling tools
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Ingredients commonly used in home and personal care (HPC) products can enter the aquatic environment after use if they are not completely removed during wastewater treatment. We investigated the occurrence and fate of a range of widespread used ingredients in HPC products in wastewater treatment plants (WWTPs) […]

New Presentation: Modelling decisions in macroinvertebrate chemical sensitivity modelling

New Presentation: Modelling decisions in macroinvertebrate chemical sensitivity modelling
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This presentation describes the construction of models predicting the sensitivity of macroinvertebrates to chemicals. Sensitivity models enable us to predict the sensitivity of species never tested before, and can help us determine which ecoregions and/or river type carry more sensitive or less sensitive species, making exposure norms […]

New Poster: The Identification of Toxicological Markers in Adverse Outcome Pathway Discovery in Chlamydomonas reinhardtii

New Poster: The Identification of Toxicological Markers in Adverse Outcome Pathway Discovery in Chlamydomonas reinhardtii
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Current regulatory toxicity testing methods have become unsuitable for the thorough assessment of chemicals for commercial use, as lack of insight into toxicological mechanism prevents accurate predictive risk assessment. Adverse outcome pathways (AOPs) offer a framework for collating mechanistic data from a diverse range of methodologies, including […]

New Presentation: Optimising the algal toxicity test towards generation of multi-omics data and adverse outcome pathway discovery

New Presentation: Optimising the algal toxicity test towards generation of multi-omics data and adverse outcome pathway discovery
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The adverse outcome pathway (AOP) concept represents a framework to organize mechanistic understanding of toxicological interactions by causally linking critical molecular key events (KE) to apical endpoints relevant for chemical risk assessment. Currently, only few methodologies can be considered for an accurate and reliable discovery and quantification […]

New Presentation: The Influence of Consumer Behaviour on the Greenhouse Gas and Water Footprints of Showering

New Presentation: The Influence of Consumer Behaviour on the Greenhouse Gas and Water Footprints of Showering
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Life Cycle Assessment (LCA) has been used as a tool for environmental footprinting of a wide range of household activities. However, despite the fact that showering is a major contributor to domestic water consumption and energy use there has been no detailed investigation of the life cycle […]

New Poster: Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence using Alginate Immbolization of Metabolic Enzymes (AIME)

New Poster: Retrofitting an Estrogen Receptor Transactivation Assay with Metabolic Competence using Alginate Immbolization of Metabolic Enzymes (AIME)
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The VM7Luc4E2 estrogen receptor (ER) transactivation assay is an OECD approved method (TG 457) for the detection of ER agonists and antagonists, and is also part of the Tox21 high-throughput screening (HTS) portfolio. Despite international acceptance as a screening assay, immortalized cell lines such as VM7Luc4E2 which […]

New Publication: mRNA transfection retrofits cell-based assays with xenobiotic metabolism

New Publication: mRNA transfection retrofits cell-based assays with xenobiotic metabolism
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The US EPA’s ToxCast program is designed to assess chemical perturbations of molecular and cellular endpoints using a variety of high-throughput screening (HTS) assays. However, existing HTS assays have limited or no xenobiotic metabolism which could lead to false positive (chemical is detoxified in vivo) as well […]

New Publication: Determination of Protein Haptenation by Chemical Sensitisers within the complexity of the Human Skin Proteome

New Publication: Determination of Protein Haptenation by Chemical Sensitisers within the complexity of the Human Skin Proteome
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This paper showcases the utility of stable isotope labelling as a method for determining the sites of covalent modification of complex proteome (haptenation) by electrophilic chemicals. This is a follow-on from the original publication using a single model protein (HSA) to initially demonstrate the method.   View […]