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NEW PUBLICATION: RISING TO THE CHALLENGE: APPLYING BIOFABRICATION APPROACHES FOR BETTER DRUG AND CHEMICAL PRODUCT DEVELOPMENT

NEW PUBLICATION: RISING TO THE CHALLENGE: APPLYING BIOFABRICATION APPROACHES FOR BETTER DRUG AND CHEMICAL PRODUCT DEVELOPMENT
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Andrew Scott provided a consumer products industry perspective on the potential applications for 3D bioprinting at the NC3Rs/InnovateUK workshop on 3D Bioprinting in December 2015. This paper provides a report from the meeting, describing needs and opportunities for the application of 3D-bio-printed tissue for safety and efficacy […]

NEW PRESENTATION: TT21C NON-ANIMAL TOXICITY TESTING STRATEGY: TEN YEARS OF INSPIRATION TO APPLICATION TO NEXT GENERATION RISK ASSESSMENTS (NGRA)

NEW PRESENTATION: TT21C NON-ANIMAL TOXICITY TESTING STRATEGY: TEN YEARS OF INSPIRATION TO APPLICATION TO NEXT GENERATION RISK ASSESSMENTS (NGRA)
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What is a Next Generation Risk Assessment (NGRA)? Ten years ago the National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. Today, through the application of these […]

NEW PRESENTATION: APPLICATION AND USE OF ‘OMICS’ DATA FOR NEXT GENERATION RISK ASSESSMENT

NEW PRESENTATION: APPLICATION AND USE OF ‘OMICS’ DATA FOR NEXT GENERATION RISK ASSESSMENT
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Application of transcriptomics to progress next generation omics assessments, focussing on the governance of the data, novel approaches, the use of omics data to aid in AOP development and in read-across weight of evidence. View the presentation.

NEW PRESENTATION: PREDICTING PHARMACOKINETICS FOLLOWING TOPICAL APPLICATION USING NON-ANIMAL METHODS

NEW PRESENTATION: PREDICTING PHARMACOKINETICS FOLLOWING TOPICAL APPLICATION USING NON-ANIMAL METHODS
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Physiologically Based Pharmacokinetic (PBPK) models are routinely used to predict human kinetic profiles of compounds. The ADME information required to build these models can be generated using differing approaches from purely in silico, through in vitro models, to extrapolation from animal models. We present an evaluation of […]

NEW PUBLICATION: AB INITIO CHEMICAL SAFETY ASSESSMENT: A WORKFLOW BASED ON EXPOSURE CONSIDERATIONS AND NON-ANIMAL METHODS

NEW PUBLICATION: AB INITIO CHEMICAL SAFETY ASSESSMENT: A WORKFLOW BASED ON EXPOSURE CONSIDERATIONS AND NON-ANIMAL METHODS
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A workflow for chemical safety assessment is described and illustrated that completely avoids animal testing. The workflow, developed within the SEURAT-1 initiative, was designed to assess chemical safety without relying on any animal testing, constructing a hypothesis based on existing data, in silico modelling, biokinetic considerations and […]

NEW PUBLICATION: A GLOBAL FRAMEWORK TO MODEL SPATIAL ECOSYSTEMS EXPOSURE TO HOME AND PERSONAL CARE CHEMICALS IN ASIA

NEW PUBLICATION: A GLOBAL FRAMEWORK TO MODEL SPATIAL ECOSYSTEMS EXPOSURE TO HOME AND PERSONAL CARE CHEMICALS IN ASIA
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This paper analyzes ecosystems spatial exposure to home and personal care (HPC) chemicals, accounting for market data, environmental processes in hydrological water basins networks, including multi-media fate and transport. We present a global modeling framework built on ScenAT (spatial scenarios of emission), SimpleTreat (sludge treatment plants), and […]

NEW PRESENTATION: SYSTEMATIC APPROACH IN THE SAFETY ASSESSMENT OF NATURALS FOR USE IN CONSUMER PRODUCTS

NEW PRESENTATION: SYSTEMATIC APPROACH IN THE SAFETY ASSESSMENT OF NATURALS FOR USE IN CONSUMER PRODUCTS
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There is a growing consumer interest in the use of natural ingredients in consumer products throughout the world often with established or perceived functional benefits. Natural ingredients can include anything sourced from nature which is unchanged, to herbal extracts processed from natural sources. Naturals are complex mixtures […]

NEW POSTER: UNILEVER, SEAC, RISK ASSESSMENT AND ALTERNATIVES TO ANIMAL TESTING.

NEW POSTER: UNILEVER, SEAC, RISK ASSESSMENT AND ALTERNATIVES TO ANIMAL TESTING.
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Scientists at Unilever’s Safety & Environmental Assurance Centre (SEAC) have played a leading role, in partnership with academic researchers, other companies, industry groups and government bodies, in the development, validation and subsequent regulatory acceptance of several non-animal methods for use in safety assessments. Since 2011, this has […]

NEW POSTER: Detoxification of the model sensitiser 2,4-dinitrochlorobenzene in Reconstructed Human Epidermis: Repeated exposure scenario

NEW POSTER: Detoxification of the model sensitiser 2,4-dinitrochlorobenzene in Reconstructed Human Epidermis: Repeated exposure scenario
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Glutathione (GSH) conjugation plays a major role in Phase II skin detoxification processes of electrophilic exogenous compounds. We used 2,4-dinitrochlorobenzene (DNCB) to investigate the effects of chemical exposure on GSH lifecycle in reconstructed human epidermis (RHE). We demonstrated that the RHE model is suitable to carry out […]

New Presentation: Development of Experimental Designs and Validation of Toxicological Markers in Adverse Outcome Pathway Discovery in Chlamydomonas reinhardtii

New Presentation: Development of Experimental Designs and Validation of Toxicological Markers in Adverse Outcome Pathway Discovery in Chlamydomonas reinhardtii
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Current regulatory toxicity testing methods have become unsuitable for the thorough assessment of chemicals for commercial use, as lack of insight into toxicological mechanism prevents accurate predictive risk assessment. Adverse outcome pathways (AOPs) offer a framework for collating mechanistic data from a diverse range of methodologies, including […]