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New Presentation: The importance of exposure considerations in safety assessment

New Presentation: The importance of exposure considerations in safety assessment
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Andrew Scott presented a talk exploring ‘The importance of exposure considerations in safety assessment’ in a Workshop session entitled Toxicology’s Next Grand Challenge: Embracing Exposure Science for Effective Public Health Protection for the Society of Toxicology (SOT) Annual Meeting in San Antonio, Texas   View the presentation.

NEW PUBLICATION: USE OF ADVERSE OUTCOME PATHWAYS (AOPs) IN HUMAN RISK ASSESSMENT AND TOXICOLOGY

NEW PUBLICATION: USE OF ADVERSE OUTCOME PATHWAYS (AOPs) IN HUMAN RISK ASSESSMENT AND TOXICOLOGY
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Carl Westmoreland was invited to co-author a book chapter for “A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment”. View the publication.

NEW POSTER: EVALUATION OF A NEXT GENERATION RISK ASSESSMENT (NGRA) APPROACH FOR SKIN ALLERGY USING SIX INGREDIENTS AND TWO PRODUCT TYPES

NEW POSTER: EVALUATION OF A NEXT GENERATION RISK ASSESSMENT (NGRA) APPROACH FOR SKIN ALLERGY USING SIX INGREDIENTS AND TWO PRODUCT TYPES
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Our aim is to apply mechanistic and clinical understanding to develop a Next Generation Risk Assessment (NGRA) approach for skin allergy that doesn’t require new animal test data, addresses novel exposure scenarios and better characterises our uncertainty. Our NGRA approach for skin allergy is a tiered approach […]

NEW PUBLICATION: HARVESTING THE PROMISE OF AOP’S: AN ASSESSMENT AND RECOMMENDATIONS

NEW PUBLICATION: HARVESTING THE PROMISE OF AOP’S: AN ASSESSMENT AND RECOMMENDATIONS
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The adverse outcome pathway (AOP) concept was developed specifically to serve as a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. However, as the AOP framework has evolved, it has become recognized that […]

NEW PUBLICATION: ADVANTAGES AND CHALLENGES ASSOCIATED WITH IMPLEMENTING AN ECOSYSTEM SERVICES APPROACH TO ECOLOGICAL RISK ASSESSMENT FOR CHEMICALS

NEW PUBLICATION: ADVANTAGES AND CHALLENGES ASSOCIATED WITH IMPLEMENTING AN ECOSYSTEM SERVICES APPROACH TO ECOLOGICAL RISK ASSESSMENT FOR CHEMICALS
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The ecosystem services (ES) approach has the potential to bring greater ecological relevance to setting and assessing environmental protection goals compared to current European regulatory frameworks for chemicals (e.g. REACH, EC 1107/2009). Scientific experts from European regulatory authorities, the chemical industry and academia discussed and evaluated the […]

NEW PRESENTATION: Microbiome research and safety approaches

NEW PRESENTATION: Microbiome research and safety approaches
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Presentation at the Innovation in the Microbiome workshop at King’s College London. View the presentation.

NEW PUBLICATION: Variability of Greenhouse Gas Footprints of Field Tomatoes Grown for Processing: Interyear and Intercountry Assessment

NEW PUBLICATION: Variability of Greenhouse Gas Footprints of Field Tomatoes Grown for Processing: Interyear and Intercountry Assessment
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Life cycle assessment (LCA) studies on agricultural products typically have limited spatial and temporal cover-age and usually overlook the interaction of farm management practices with farm-specific factors and environ-mental conditions. We provide the first integrated analysis of the drivers of variability in greenhouse gas (GHG) footprints of […]

NEW PUBLICATION: RISING TO THE CHALLENGE: APPLYING BIOFABRICATION APPROACHES FOR BETTER DRUG AND CHEMICAL PRODUCT DEVELOPMENT

NEW PUBLICATION: RISING TO THE CHALLENGE: APPLYING BIOFABRICATION APPROACHES FOR BETTER DRUG AND CHEMICAL PRODUCT DEVELOPMENT
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Andrew Scott provided a consumer products industry perspective on the potential applications for 3D bioprinting at the NC3Rs/InnovateUK workshop on 3D Bioprinting in December 2015. This paper provides a report from the meeting, describing needs and opportunities for the application of 3D-bio-printed tissue for safety and efficacy […]

NEW PRESENTATION: TT21C NON-ANIMAL TOXICITY TESTING STRATEGY: TEN YEARS OF INSPIRATION TO APPLICATION TO NEXT GENERATION RISK ASSESSMENTS (NGRA)

NEW PRESENTATION: TT21C NON-ANIMAL TOXICITY TESTING STRATEGY: TEN YEARS OF INSPIRATION TO APPLICATION TO NEXT GENERATION RISK ASSESSMENTS (NGRA)
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What is a Next Generation Risk Assessment (NGRA)? Ten years ago the National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. Today, through the application of these […]

NEW PRESENTATION: APPLICATION AND USE OF ‘OMICS’ DATA FOR NEXT GENERATION RISK ASSESSMENT

NEW PRESENTATION: APPLICATION AND USE OF ‘OMICS’ DATA FOR NEXT GENERATION RISK ASSESSMENT
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Application of transcriptomics to progress next generation omics assessments, focussing on the governance of the data, novel approaches, the use of omics data to aid in AOP development and in read-across weight of evidence. View the presentation.