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Understanding biotransformation of slowly cleared chemicals in in vitro models including 3D liver Spheroid and HepatoPac.

Understanding biotransformation of slowly cleared chemicals in in vitro models including 3D liver Spheroid and HepatoPac.
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The transition to a pathway-based approach for risk assessment will require better understanding of exposure science. One of those approaches is to understand the bioavailability of chemicals in the human body and define toxicologically relevant approaches that permit the estimation of internal dose in humans. Physiologically-based biokinetic […]

New Poster: Immune responses to repeated application of the contact allergen diphenylcyclopropenone (DPC) in humans: evidence of down-regulatory mechanisms

New Poster: Immune responses to repeated application of the contact allergen diphenylcyclopropenone (DPC) in humans: evidence of down-regulatory mechanisms
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This research to understand the underpinning immune response in alopecia patients undergoing treatment with the experimental skin sensitiser diphenylcyclopropenone (DPC) is part of our T cell forum programme of research, which aims to improve skin allergy risk assessment through increased mechanistic and clinical understanding. View the poster […]

New Presentation: Determination of Protein Haptenation by Chemical Sensitisers within the Complexity of the Human Skin Proteome

New Presentation: Determination of Protein Haptenation by Chemical Sensitisers within the Complexity of the Human Skin Proteome
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Skin sensitisation associated with the development of allergic contact dermatitis (ACD) occurs via a number of specific key events at the cellular level. The molecular initiating event (MIE), the first in the sequence of these events, occurs after exposure of the skin to an electrophilic chemical, causing […]

New Presentation: Characterisation of T lymphocyte responses in nickel and paraphenylene diamine allergic patients

New Presentation: Characterisation of T lymphocyte responses in nickel and paraphenylene diamine allergic patients
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This research to understand the underpinning immune response in patients diagnosed as contact allergic to nickel and paraphenylene diamine (PPD) by patch testing is part of our T cell forum programme of research, which aims to improve skin allergy risk assessment through increased mechanistic and clinical understanding. […]

New Poster: Allergic contact dermatitis: characterising the relationship between T cells and skin sensitising potency

New Poster: Allergic contact dermatitis: characterising the relationship between T cells and skin sensitising potency
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Poster summarises the activities of our T cell forum research network who have been researching the relationship between T cell responses and skin sensitising potency by characterising blood samples from Allergic Contact Dermatitis patients since 2012 as part of our research to develop and apply next generation […]

New Poster: Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists

New Poster: Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists
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Poster presentation ESCD 2018 Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists. View the poster here.

New Poster: Next-Generation skin allergy Risk Assessment case study: Evaluation of four ingredients and two product types without using animal test data

New Poster: Next-Generation skin allergy Risk Assessment case study: Evaluation of four ingredients and two product types without using animal test data
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Next Generation Risk Assessment (NGRA) case study poster presented at ESCD 2018 18th – 20th October. View the poster here.

New Presentation: Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research

New Presentation: Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research
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Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research. View the presentation here.

New Poster: Principles for the safety evaluation of cosmetic powders

New Poster: Principles for the safety evaluation of cosmetic powders
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Although the consumer exposure to the vast majority of cosmetic products is limited to dermal contact, additional considerations with regards to potential inhalation exposure from some cosmetics, such as sprays and powders, may be needed for a robust and reliable safety assessment. To get a full understanding […]

New Presentation: Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios

New Presentation: Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios
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Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios. View the presentation here.