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New Presentation: Characterisation of T lymphocyte responses in nickel and paraphenylene diamine allergic patients

New Presentation: Characterisation of T lymphocyte responses in nickel and paraphenylene diamine allergic patients
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This research to understand the underpinning immune response in patients diagnosed as contact allergic to nickel and paraphenylene diamine (PPD) by patch testing is part of our T cell forum programme of research, which aims to improve skin allergy risk assessment through increased mechanistic and clinical understanding. […]

New Poster: Allergic contact dermatitis: characterising the relationship between T cells and skin sensitising potency

New Poster: Allergic contact dermatitis: characterising the relationship between T cells and skin sensitising potency
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Poster summarises the activities of our T cell forum research network who have been researching the relationship between T cell responses and skin sensitising potency by characterising blood samples from Allergic Contact Dermatitis patients since 2012 as part of our research to develop and apply next generation […]

New Poster: Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists

New Poster: Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists
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Poster presentation ESCD 2018 Improving skin allergy risk assessment: opportunities for collaboration between clinicians and toxicologists. View the poster here.

New Poster: Next-Generation skin allergy Risk Assessment case study: Evaluation of four ingredients and two product types without using animal test data

New Poster: Next-Generation skin allergy Risk Assessment case study: Evaluation of four ingredients and two product types without using animal test data
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Next Generation Risk Assessment (NGRA) case study poster presented at ESCD 2018 18th – 20th October. View the poster here.

New Presentation: Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research

New Presentation: Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research
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Next Generation Skin Allergy Risk Assessment: opportunities to reduce uncertainty through research. View the presentation here.

New Poster: Principles for the safety evaluation of cosmetic powders

New Poster: Principles for the safety evaluation of cosmetic powders
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Although the consumer exposure to the vast majority of cosmetic products is limited to dermal contact, additional considerations with regards to potential inhalation exposure from some cosmetics, such as sprays and powders, may be needed for a robust and reliable safety assessment. To get a full understanding […]

New Presentation: Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios

New Presentation: Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios
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Evaluation of Next-Generation Risk Assessment (NGRA) Approach for Skin Allergy using four ingredients and two product exposure scenarios. View the presentation here.

New Presentation: Next generation risk assessment for consumer safety of cosmetics: A case study approach

New Presentation: Next generation risk assessment for consumer safety of cosmetics: A case study approach
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The principles for the use of non-animal approaches in consumer safety risk assessments were recently outlined by the International Cooperation on Cosmetics Regulation (ICCR). A key principle is that modern risk assessments should be exposure led. This means that novel methods that are used to make decisions […]

New Presentation: Mitochondrial toxicity and oxidative stress: Defining the tipping point between adaptive and adverse effects for consumer safety risk assessment

New Presentation: Mitochondrial toxicity and oxidative stress: Defining the tipping point between adaptive and adverse effects for consumer safety risk assessment
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Within emerging Next Generation Risk Assessment (NGRA) frameworks, oxidative stress and mitochondrial toxicity are included as early key events in several Adverse Outcome Pathways (AOPs). A key challenge is to understand how dose-response information from non-animal approaches to studying cell stress/mitochondrial toxicity can be integrated with consumer […]

New Presentation: High-throughput and non-depletive quantification in 3D liver microtissue in-vitro assay

New Presentation: High-throughput and non-depletive quantification in 3D liver microtissue in-vitro assay
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Non-animal approaches for assessing toxicological and environmental risk of ingredients require more advanced and realistic in-vitro models as well as a better understanding of a chemicals distribution and fate in-vitro and in-vivo. Here we applied a novel ultra-thin SPME fiber sampling method to analyse the fate of […]