NEW PUBLICATION: HARVESTING THE PROMISE OF AOP’S: AN ASSESSMENT AND RECOMMENDATIONS

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The adverse outcome pathway (AOP) concept was developed specifically to serve as a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. However, as the AOP framework has evolved, it has become recognized that the potential stakeholder community for the concept and associated knowledge is broader than scientists and regulators directly involved in chemical safety assessment. For example, the tractability of AOP-based approaches for addressing biomedical challenges has become increasingly evident. In this paper we identify those stakeholders who currently¿or in the future¿could benefit from the application of the AOP framework and knowledge to specific problems, and suggest strategies to engage these stakeholders more effectively. We describe and provide the stakeholders that the AOP framework must engage with, the challenges faced, and recommendations to meet critical needs to ensure further progression of the AOP framework as a useful, sustainable and dependable tool for chemical-effect assessment for both human health and the environment. We identify a pressing need to engage a multi-stakeholder consortium responsible for governance and coordination of AOP development and knowledge dissemination, as well as ensure stable resourcing for key IT/web infrastructure.

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